Prefect: H.E. Cardinal José Tolentino de Mendonça
Secretary: Bishop Paul Desmond Tighe, titular Bishop of Drivastrum (Culture Section)
Secretary: Rev. Msgr. Giovanni Cesare Pagazzi (Education Section)
Under-Secretary: Prof. Antonella Sciarrone Alibrandi
Under-Secretary: Father Antonino Spadaro, S.J.
Under-Secretary: Msgr. Matthias Ambros
Adjunct Under-Secretary: Msgr. Carlo Maria Polvani