The Office consists of:
- an Auditor General who directs and represents the Office; this role is currently entrusted to Alessandro Cassinis Righini.
- a group of Auditors with solid and proven professional experience;
- support personnel.
The Auditor General is appointed ad quinquennium by the Holy Father and chosen among persons of proven reputation, who do not exercise activities that are incompatible with the appointment, who are free from any conflict of interest, and who have recognized professional competence and skills in the relevant areas concerning the work of the Office. The Auditor General may be appointed only for two terms.